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目的观察P16在甲状腺乳头状癌中的表达及其生物学意义。方法收集132例行甲状腺乳头状癌手术切除标本和同期住院的40例甲状腺瘤组织,应用免疫组化SP方法测定P16基因表达并分析甲状腺乳头状癌临床病理参数与基因表达的关系。结果 P16在甲状腺乳头状癌组织中的表达率低于甲状腺瘤组织(P<0.05),P16的表达与转移、复发有关(P<0.05),与性别、年龄、肿瘤大小、临床分期无关(P>0.05)。结论 P16可能参与了甲状腺乳头状癌的发生和发展,并进而影响其生物学特点及预后。
Objective To observe the expression of P16 in papillary thyroid carcinoma and its biological significance. Methods Thirty-two thyroid tumors were collected from 132 patients with papillary thyroid carcinoma and 40 thyroid tumors in the same hospital. The expression of P16 gene was detected by immunohistochemical SP method and the relationship between the clinicopathological parameters and gene expression was analyzed. Results The positive rate of P16 in thyroid papillary carcinoma was lower than that in thyroid adenoma (P <0.05). The expression of P16 was related to metastasis and recurrence (P <0.05), but not to gender, age, tumor size and clinical stage > 0.05). Conclusion P16 may be involved in the occurrence and development of papillary thyroid carcinoma, and then affect its biological characteristics and prognosis.