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目的:探讨多种因素对AID治疗结局的影响。方法:回顾2008年11月~2010年5月在生殖中心实施AID助孕治疗的418名妇女639个治疗周期的病例,综合分析不孕妇女的年龄、输卵管情况、治疗周期、促排卵用药及授精次数等因素对AID治疗妊娠结局的影响。结果:AID周期妊娠率为34.90%(223/639),例数妊娠率为53.34%(223/418)。临床妊娠率与女方年龄、是否合并输卵管因素、授精与排卵时间等有一定关系。排卵前后短时内单次授精的平均妊娠率反而高于排卵前后双次授精。639个AID周期中,随治疗周期的增加累计妊娠率随之增高,但周期妊娠率下降,第1~3周期临床妊娠率依次为37.08%、31.98%、21.95%。AID促排卵周期妊娠率与自然周期无差异(34.02%、35.63%)。结论:不孕妇女的年龄、输卵管情况及授精时机的掌握是影响供精人工授精成功率的重要因素。对超过3周期仍不孕者,可考虑改行供精体外授精-胚胎移植进行助孕。
Objective: To explore the effect of various factors on the outcome of AID. Methods: A retrospective review of 418 cases of 418 women treated with AID in the reproductive center from November 2008 to May 2010 was conducted. The age, fallopian tube, treatment cycle, ovulation induction and insemination of infertile women were analyzed comprehensively The number of times and other factors on the outcome of pregnancy AID treatment. Results: The pregnancy rate of AID cycle was 34.90% (223/639), and the pregnancy rate of cases was 53.34% (223/418). Clinical pregnancy rate and the woman’s age, whether the combined tubal factors, fertilization and ovulation time have a certain relationship. The average pregnancy rate of single insemination in short time before and after ovulation was higher than that of double insemination before and after ovulation. In the 639 AID cycles, the cumulative pregnancy rate increased with the increase of the treatment period, but the pregnancy rate decreased. The pregnancy rates in the first to third cycles were 37.08%, 31.98% and 21.95%, respectively. AID ovulation cycle pregnancy rate and the natural cycle no difference (34.02%, 35.63%). Conclusion: The infertile women’s age, fallopian tube situation and the timing of insemination are the important factors affecting the success rate of artificial insemination. For more than 3 cycles are still infertile, consider diverting for sperm-embryo transfer for pregnancy.