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~8H-莪术醇自大鼠胃肠道吸收迅速且完全。灌胃后5分钟血中即有放射性,15分钟达高峰,1小时仍保持较高浓度,放射性自血中消失的生物半衰期为11.5小时(t_(1/2)β)。静脉注射后血中放射性的消失分快、慢两相,生物半衰期分别为33分钟(t_(1/2)α)及12.5小时(t_(1/2)β)。 放射性在正常大鼠体内分布情况与肿瘤小鼠者相似。肝及肾组织含量约为其它组织的2～2.5倍。肿瘤组织中的分布与其它组织无明显差别;组织中放射性的消失与血浆中者略呈平行关系。放射性与脂肪组织似有较强的亲和力,给药后4小时仍维持较高水平。 放射性主要自尿排泄,口服或静脉注射后24小时分别自大鼠尿排出剂量的45.38％及51.91％。胆汁为另一排泄途径,大鼠口服或静脉注射后24小时,分别自胆汁排出36.47％及56.43％,而口服或静脉注射后72小时仅从粪回收6.77％及14.35％,可见,自胆汁排出的放射性大部分均又被重吸收入血。
~ 8 E Curcuma alcohol absorption from the gastrointestinal tract quickly and completely. 5 minutes after intragastric administration of radioactive blood that reached the peak at 15 minutes, 1 hour remained at a high concentration of radioactive disappearance of blood biological half-life of 11.5 hours (t_ (1/2) β). After the intravenous injection, the disappearance of radioactive blood was divided into fast and slow two phases, and the biological half-lives were 33 minutes (t 1/2 (1/2) α) and 12.5 hours (t 1/2 (β 1/2), respectively). Radioactivity distribution in normal rats and tumor mice were similar. Liver and kidney tissue content is about 2 ~ 2.5 times that of other tissues. There was no significant difference between the distribution of tumor tissue and other tissues; the disappearance of radioactivity in tissues was slightly parallel to those in plasma. Radioactive and adipose tissue seems to have a strong affinity 4 hours after administration still maintain a high level. Radioactive mainly from urinary excretion, oral or intravenous injection of rat urine from 45.38% and 51.91% respectively. Bile is another excretion pathway. After 24 hours of oral or intravenous injection, rats respectively excrete 36.47% and 56.43% of bile, while only 6.77% and 14.35% of excretions recovered 72 hours after oral or intravenous injection. Most of the radioactivity was re-absorbed into the blood.