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目的:研究CXCR4及MMP-3的表达与大小肾癌生物学特性的关系。方法:在上海市第一人民医院泌尿外科2004年6月至2010年12月行手术治疗的肾癌患者里,任意抽出20例癌旁正常组织,30例小肾癌,30例大肾癌的标本,检验大小肾癌及正常肾组织中CXCR4及MMP-3的表达情况。结果:肾癌中CXCR4和MMP-3的表达高于癌旁正常肾组织(P<0.01),大肾癌CXCR4,MMP-3的表达高于小肾癌(P<0.05)。肾癌中两者的相关表达呈正相关。结论:MMP-3,CXCR4在小肾癌中的低表达可能预示了小肾癌恶性程度低、侵袭和转移能力小的生物学特点,可以预测肾癌的进展。
Objective: To investigate the relationship between the expression of CXCR4 and MMP-3 and the biological characteristics of renal cell carcinoma of large and small size. Methods: Twenty cases of normal adjacent tissues, 30 cases of small renal cell carcinoma and 30 cases of large renal cell carcinoma were randomly selected from Department of Urology, Shanghai First People ’s Hospital from June 2004 to December 2010. Specimens, test the size of renal cell carcinoma and normal renal tissue CXCR4 and MMP-3 expression. Results: The expressions of CXCR4 and MMP-3 in renal cell carcinoma were significantly higher than those in adjacent normal tissues (P <0.01). The expression of CXCR4 and MMP-3 in large renal cell carcinoma was higher than that in small renal cell carcinoma (P <0.05). Correlation between the expression of the two in renal cell carcinoma was positively correlated. Conclusion: The low expression of MMP-3 and CXCR4 in small renal cell carcinoma may predict the biological characteristics of small renal cell carcinoma with low malignant degree and low invasion and metastasis, which can predict the progression of renal cell carcinoma.