作者观察了用含碘的抗心律失常药物治疗的病人,不论治疗前病人有无甲状腺病,都可引起甲状腺毒症。有一些过去无甲状腺病的病人,用药后甲状腺可以出现弥漫的、软的无痛性肿大。当停药后,上述现象可以消失。严重的甲状腺毒症病人的症状与用大剂量碘剂治疗病人产生的危象相似。其原因是因为贮存了丰富的碘化甲状腺球蛋白妨碍了对硫酰胺的反应,以及Wolff-Chaikoff反应 The authors looked at patients treated with iodine-containing anti-arrhythmic drugs that cause thyrotoxicosis regardless of whether the patient had thyroid disease before treatment. Some patients with thyroid disease in the past, the administration of thyroid can be diffuse, soft painless swelling. When stopped, the above phenomenon can disappear. Symptoms of patients with severe thyrotoxicosis are similar to those of patients treated with high doses of iodine. The reason for this is that the storage of abundant iodated thyroglobulin prevents the reaction with the sulfamide, and the Wolff-Chaikoff reaction