氨基糖苷类抗生素可出现肾毒性、耳毒性、神经肌肉阻断和变态反应等不良反应。研究发现每日1次给药方案,不仅使肾毒性的风险降低,且与每日多次给药具有同样的疗效。但在粒细胞缺乏症伴发热患者中,每日1次或多次给予氨基糖苷类治疗效果是否有差别存在争议。本研究对2种给药方案的有效性、安全性及病死率等进行系统回顾与荟萃分析,为临床用药提供有效信息。 Aminoglycoside antibiotics may appear nephrotoxicity, ototoxicity, neuromuscular blocking and allergic reactions and other adverse reactions. The study found that once-a-day dosing regimens not only reduced the risk of nephrotoxicity but also had the same effect as multiple daily doses. However, in patients with agranulocytosis with fever, one or more daily doses of aminoglycosides are controversial. This study systematically reviews and meta-analyzes the efficacy, safety, and mortality of the two dosing regimens to provide valid information for clinical use.