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目的分析濮阳市2015年疑似预防接种异常反应(AEFI)的特征,评价AEFI监测系统运转情况,分析疫苗的安全性和预防接种服务质量。方法通过中国免疫规划信息管理系统收集全市2015年报告的AEFI个案数据,采用描述性方法对相关指标进行流行病学分析。结果濮阳市2015年共报告AEFI 382例,报告发生率为2.14/万剂。其中一般反应363例(95.03%),异常反应19例(4.97%),未出现疫苗质量事故、接种事故、偶合症和心因性反应报告病例,无严重AEFI发生。一般反应以发热、红肿、硬结为主,异常反应以过敏性皮疹、荨麻疹、斑丘疹为主。男女比例1.08:1,主要发生于≤2岁儿童,占85.86%,发生数最多的是无细胞百白破94例(24.61%),纳入国家免疫计划(NIP)疫苗中报告发生率最高的麻风疫苗为10.30/万剂,全市对发生的AEFI能及时报告和流调,各项监测指标均达到监测方案要求。结论监测结果表明全市AEFI监测系统运转正常,免疫规划疫苗安全性与预防接种服务质量良好。
Objective To analyze the characteristics of suspected anonymous immunization (AEFI) in 2015 in Puyang, assess the operation of AEFI monitoring system, analyze the safety of vaccine and the quality of vaccination services. Methods The AEFI case data of the city’s 2015 report was collected through China’s immunization planning information management system, and the descriptive method was used to conduct epidemiological analysis on related indicators. Results A total of 382 AEFI cases were reported in Puyang in 2015, with a reported incidence of 2.14 per 10,000 doses. There were 363 cases (95.03%) of the general reactions and 19 cases (4.97%) of the abnormal reactions. No cases of vaccine quality accidents, vaccination accidents, complications and cardiogenic reactions were reported, and no serious AEFI occurred. The general reaction to fever, redness, induration mainly abnormal reaction to an allergic rash, urticaria, macular rash. The ratio of males to females was 1.08: 1, which mainly occurred in children ≤2 years old, accounting for 85.86%. The most frequent cases occurred in 94 cases (24.61%) of patients with aplastic anemia. The highest incidence of leprosy was reported in the national immunization program (NIP) The vaccine was 10.30 / ten thousand doses. The AEFI that occurred in the whole city was able to timely report and adjust the flow. The monitoring indicators met the monitoring program requirements. Conclusion The monitoring results show that the AEFI monitoring system in the city is in normal operation, and the immunization program vaccine safety and immunization services are of good quality.