采用外周血淋巴细胞培养方法对39例系统性红斑狼疮(SLE)患者和22例一级亲属进行淋巴细胞姊妹染色单体互换(SCE)频率和细胞周期动力学(CK)测定,发现SLE患者和亲属的SCE频率明显增高,细胞周期延长,细胞增殖率下降,提示SLE患者存在着淋巴细胞质和量的异常,遗传因素在SLE发病中起重要作用;这种遗传素质的来源不仅存在于亲代亲属之间,而且存在于同胞亲属。 Thirty-nine patients with systemic lupus erythematosus (SLE) and 22 first-degree relatives were analyzed for lymphocyte Sister Chromatid Exchange (SCE) frequency and cell cycle kinetics (CK) using peripheral blood lymphocyte culture. SLE patients And relatives increased significantly SCE frequency, cell cycle, cell proliferation rate decreased, suggesting that SLE patients with lymphocyte quality and quantity abnormalities, genetic factors play an important role in the pathogenesis of SLE; this genetic quality is not only present in the relatives of relatives Between, but also in relatives of siblings.