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奥曲肽(octreotide)的作用与生长抑素基本相同,对胃肠系有多方面的作用,包括:抑制胃肠肽如胃泌素、胰高糖素、胰岛素、胆囊收缩素和血管活性肠肽(VIP)的分泌,抑制胃酸和胰酶的分泌,促进水和电解质的吸收,延缓胃肠道通过时间,减少内脏血流量和肝脏血流量。根据这些药理作用,可用以治疗不同种类的消化系病。此外,对胃肠内分泌瘤和嗜银细胞瘤有抑制或限制其生长的作用。皮下注射吸收完全,生物利用度80％～135％。体内分布迅速,约65％与血浆脂蛋白和白蛋白结合。清除半衰期(T_(1/2)β)为1.5h。在严重肾功能衰竭时,清除
Occuptic acts like somatostatin and has multiple effects on the gastrointestinal tract, including the inhibition of gastrointestinal peptides such as gastrin, glucagon, insulin, cholecystokinin and vasoactive intestinal peptide ( VIP) secretion, inhibition of gastric acid and pancreatic enzyme secretion, promote the absorption of water and electrolytes, delay gastrointestinal passage time, reduce visceral blood flow and liver blood flow. According to these pharmacological effects, can be used to treat different types of digestive diseases. In addition, gastrointestinal endodermal and neuroblastoma inhibit or limit the growth of the role. Subcutaneous injection of complete absorption, bioavailability of 80% to 135%. Rapidly distributed in vivo, about 65% of plasma lipoprotein and albumin binding. Clear half-life (T_ (1/2) β) was 1.5h. In severe renal failure, clear