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目的探讨C-反应蛋白(CRP)rs1130864基因位点与缺血性卒中(IS)的相关性。方法 64例IS患者设定为研究组,并选取同时间段内无动脉粥样硬化血管病史体检者56例作为对照组,检测两组rs1130864位点基因型,分析IS相关危险因素。结果两组患者rs1130864位点基因型、等位基因频率及显性模型对比差异无统计学意义(P>0.05),隐性模型对比差异有统计学意义(P<0.05);Logistic回归分析表明男性、高血压病史、糖尿病史、吸烟史、rs1130864隐性模型(TT+CT)均属于IS发生的危险因素。结论 C-反应蛋白rs1130864基因位点与缺血性卒中具有一定相关性。
Objective To investigate the relationship between C-reactive protein (CRP) rs1130864 locus and ischemic stroke (IS). Methods Sixty-four patients with IS were enrolled in the study group. Fifty-six patients with no history of atherosclerotic vascular disease during the same period were selected as the control group. Genotypes of rs1130864 locus in both groups were detected, and IS-related risk factors were analyzed. Results There was no significant difference in genotype, allele frequency and dominant model between rs1130864 locus and control group (P> 0.05), but there was significant difference between two groups (P <0.05). Logistic regression analysis showed that male , History of hypertension, history of diabetes, history of smoking, and rs1130864 recessive model (TT + CT) all belong to the risk factors of IS. Conclusion C-reactive protein rs1130864 locus has some correlation with ischemic stroke.