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一、研究对象对于从1979年到1985年的7年间,以口干为主诉来院就诊的、怀疑是Sjogren综合征的105例中,对其中的97例进行下唇小唾液腺活检,根据厚生省干燥综合症诊断标准,确诊的62例(女61例,男1例),疑似的35例(女33例,男2例)。二、研究方法 1.小唾液腺活检:按通常的方法,从下唇正中部内侧摘出小唾液腺,以10％甲醛固定后行HE染色,制成标本镜检,进行单核细胞的计算。 2.组织变化程度的分类:参考Chisholm and Mason分类,根据导管周围单核细胞的浸润程度而分为5级,即1级:未出现细胞浸润或极轻度浸润。2级:轻度(氵弥)漫性浸润。3级:中度(氵弥)漫性浸润或根据厚生省的诊断标准,一个视野单核细胞在50个以上。4级:高度浸润,间质全部呈(氵弥)漫性或局限性浸润。5级:高度浸润,特别限局于导管周围。
First, the research object For the seven years from 1979 to 1985, 105 patients with suspected Sjogren syndrome who came to the hospital with dry mouth as main complaints, 97 of them underwent small salivary gland biopsy of the lower lip, according to the dry synthesis of the Ministry of Health and Welfare Diagnostic criteria, diagnosed in 62 cases (61 females, 1 male), suspected of 35 cases (33 females, 2 males). Second, research methods 1. Small salivary gland biopsy: According to the usual method, from the middle part of the lower lip out of the small salivary glands, fixed with 10% formaldehyde HE staining, made specimen microscopic examination, monocyte count. 2. Classification of the degree of tissue change: Refer to the Chisholm and Mason classification, according to the degree of infiltration of mononuclear cells around the catheter is divided into 5 levels, namely 1: no cell infiltration or very mild infiltration. Grade 2: Mild (patchy) diffuse infiltration. Grade 3: Moderate (infertility) diffuse infiltration or according to the diagnostic criteria of the Ministry of Health, a field of view of monocytes in more than 50. Grade 4: Highly infiltrated, with all interstitials showing diffuse or localized infiltration. Grade 5: Highly infiltrated, especially around the catheter.