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以往数月中,通过人体肿瘤的细胞癌基因研究和染色体异常分析揭示了两者之间存在新的联系。这些发现引起了人们极大的兴趣。在各种类型的肿瘤中,人细胞癌基因在染色体上的位置和染色体易位与缺失的断裂点之间的显著相关性逐步趋于明显。癌基因c-mos、c-myc 和c-abl 分别位于急性粒细胞性白血病(AML)、Burkitt 淋巴瘤和慢性粒细胞性白血病(CML)的8;21、8;14和9;22易位的断裂点上,而c-ras~(?)则位于无虹膜-肾胚瘤综合征患者所缺失的位点上。附图总结了各特殊染色体上癌基因的位置,影响染色体的非随机变化和常见的核型异常疾病。人们早就知道,在人体肿瘤中存
In the past few months, cell oncogene studies and chromosomal abnormalities analysis of human tumors revealed a new link between the two. These discoveries have caused great interest. In various types of tumors, the significant correlation between the location of the human cell oncogene on chromosomes and the breakpoints of chromosomal translocations and deletions gradually becomes apparent. The oncogenes c-mos, c-myc, and c-abl are located in acute myelogenous leukemia (AML), Burkitt lymphoma, and chronic myeloid leukemia (CML) 8;21,8;14, and 9;22 translocations, respectively; At the point of rupture, c-ras~(?) is located at the site of absence of the iris-renal blastoma syndrome. The figures summarize the location of oncogenes on specific chromosomes, affect non-random chromosome changes, and common karyotypic abnormalities. People have long known that they exist in human tumors