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经导管股动脉插管化疗栓塞治疗晚期直肠癌28例。治疗后全组病人临床症状均有明显改善.肿瘤病灶缩小>50%者5例(18.2%);缩小25%~50%者12例(43.4%);小于25%者6例(21.4%);无变化者5例。4例经治疗后,肿瘤病灶明显缩小,获得二期手术切除。术后病理检查发现肿瘤细胞大部分有变性坏死和炎性反应.有大量淋巴细胞浸润。其中1例肿瘤病灶已全部纤维化,无残留癌细胞存活。因此插管化疗栓塞治疗直肠癌可以提高手术切除率,降低术后局部复发及肝脏转移,为一新的治疗方法。
Transcatheter femoral arterial chemoembolization was performed in 28 patients with advanced rectal cancer. After treatment, the clinical symptoms of the whole group of patients were significantly improved. The tumor lesions were reduced by >50% in 5 patients (18.2%); in patients with 25% to 50% in 12 patients (43.4%), in patients with less than 25% in 6 patients (21.4%), and in 5 patients without change. After treatment in the 4 cases, the tumor lesions were significantly reduced and surgical resection was performed in the second stage. Postoperative pathological examination revealed that most of the tumor cells had degeneration, necrosis, and inflammatory reaction. There is a lot of lymphocyte infiltration. One of the tumor lesions had become fibrotic and no residual cancer cells survived. Therefore, intubation chemoembolization for rectal cancer can improve the resection rate, reduce postoperative local recurrence and liver metastasis, and is a new treatment method.