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目的探讨幽门螺杆菌(Hp)细胞毒素相关蛋白(CagA)与慢性胃炎患儿胃窦黏膜炎症程度、Hp定植密度的关系。方法对79例Hp相关性慢性胃炎患儿采用免疫印迹法检测血清CagA抗体,并行胃镜检查,取胃窦黏膜经HE及改良Giemsa 染色后观察胃窦黏膜炎症程度及Hp定植密度。结果79例Hp相关性慢性胃炎患儿血清CagA抗体阳性67例(84.81%),其中胃窦黏膜轻度炎症9例(13.43%),中重度炎症58例(86.57%),而12例血清CagA抗体阴性患儿胃窦黏膜轻度炎症7例(58 33%),中重度炎症5例(41 67%),两者差异有显著性(x2=10.076 P=0.002),而两组胃窦黏膜Hp定植密度无明显差异(H=0.246 P-0 884)。结论CagA与慢性胃炎患儿胃窦黏膜炎症程度有关.而与Hp在胃窦部的定植密度无关,CagA 阳性Hp菌株能引起胃窦黏膜较重炎症。
Objective To investigate the relationship between Helicobacter pylori (Hp) cytotoxin-related protein (CagA) and gastric antral mucosal inflammation and Hp colonization density in children with chronic gastritis. Methods Serum CagA antibody was detected in 79 children with Hp-related chronic gastritis by gastroscope. Gastric sinusitis was examined by gastroscopy. The antral mucosa was stained with HE and modified Giemsa to observe the degree of inflammation and Hp colonization density. Results Serum CagA antibody was found in 67 cases (84.81%) of 79 Hp-related chronic gastritis patients, of which 9 (13.43%) had mild inflammation of the antral mucosa, 58 (86.57%) had moderate or severe inflammation, while 12 Seven patients (58.33%) had mild inflammation of antral mucosa, 5 patients (41.67%) had moderate or severe inflammation, the difference was significant (x2 = 10.076 P = 0.002) There was no significant difference in Hp colonization density (H = 0.246 P-0 884). Conclusion CagA is related to the degree of inflammation of antral mucosa in children with chronic gastritis, but not with the density of Hp in the gastric antrum. CagA-positive Hp strains can cause severe inflammation of gastric mucosa.