肿瘤血管是肿瘤生长和浸润转移的形态学基础,不仅向肿瘤组织提供营养,也向肿瘤宿主输出大量肿瘤细胞,导致肿瘤的扩散和转移。肿瘤血管形成是一个复杂过程,与基因改变、多种细胞因子的调控及细胞外基质和微循环环境的改变均有关系。VEGF是促进血管生成的主要调节因子,在肿瘤的生 Tumor blood vessels are the morphological basis of tumor growth and invasion and metastasis, which not only provide nutrition to tumor tissues, but also output a large amount of tumor cells to tumor hosts, resulting in the spread and metastasis of tumors. Tumor angiogenesis is a complicated process, which is related to gene changes, the regulation of various cytokines and the changes of extracellular matrix and microcirculation environment. VEGF is a major regulator of angiogenesis in tumorigenesis