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目的 :研究具有较低居里点温度的磁性材料 ,在高频电磁场作用下产热对肿瘤的影响。方法 :将镍铜合金制作的居里点温度为 6 0℃的柱状磁性材料植入小鼠 S1 80 内 ,从体外用高频电磁场诱导植入瘤体内的磁性材料感应产热 ,观察瘤体的温度变化和加热后的病理改变、瘤体大小及动物生存时间等。结果 :185 k Hz、6 m T的高频电磁场诱导植入瘤体内的磁性材料产热可使小鼠瘤体中心温度迅速升高达 48℃ ,并使瘤体在持续加热中维持这一温度水平 ;瘤体周围与肿瘤交界处的正常组织温度升高并不明显 ,肿瘤组织出现大片坏死 ,6 0 %小鼠瘤体消失 ,生存期明显延长。结论 :用高频电磁场诱导肿瘤内磁性材料可达到内加热定向治疗肿瘤和加热温度自动控制。
Objective : To study the effect of heat production on the tumor under the action of high-frequency electromagnetic field in magnetic materials with low Curie temperature. METHODS: The columnar magnetic material with a Curie point temperature of 60 °C made of nickel-copper alloy was implanted into the mouse S1 80. The induction of heat from the magnetic material implanted in the tumor body was induced by high-frequency electromagnetic fields in vitro. Changes in temperature and pathological changes after heating, tumor size, and animal survival time. RESULTS: The 185 k Hz and 6 m T high-frequency electromagnetic fields induced the heat production of the magnetic material implanted in the tumor to rapidly increase the center temperature of the mouse tumor up to 48°C, and maintain the temperature of the tumor body during continuous heating. The temperature of the normal tissues around the junction of the tumor and the tumor was not obvious. There was a large necrosis in the tumor tissue, 60% of the tumors disappeared in mice, and the survival time was prolonged. Conclusion : Induction of magnetic material in tumor by high frequency electromagnetic field can achieve automatic control of internal heating and tumor treatment and heating temperature.