论文部分内容阅读
目的:对比分析痛风与单纯高尿酸血症合并高脂血症的情况。方法:收集青岛大学附属医院痛风专病门诊2009年5月至2016年1月收治的痛风患者7207例(男性6759例,女性448例),单纯高尿酸血症患者2095例(男性1852例,女性243例)。测量受试者身高、体重、腰围、臀围、血压、空腹血糖(FPG)、血甘油三酯(TG)、血胆固醇(TC)及血尿酸(UA),计算并比较两组高甘油三脂血症、高胆固醇血症的患病率,并分析其在痛风发生中的独立作用。结果:痛风组高甘油三酯血症和高胆固醇血症的患病率分别为57.8%、47.5%;单纯高尿酸血症组为51.8%、52.9%;两组率相比的比值比,高甘油三脂血症1.274[95%CI(1.155,1.404)],胆固醇血症0.805[95%CI(0.730,0.887)]。按性别分层分析,男性痛风组高甘油三脂血症、高胆固醇血症患病率分别为56.2%,46.8%;单纯高尿酸血症组分别为52.3%,52.6%。两组率相比的比值比,高甘油三脂血症1.25[95CI%(1.13,1.39)],高胆固醇血症0.80[95CI%(0.72,0.89)]。女性中痛风组高甘油三脂血症、高胆固醇血症患病率分别为52.2%,58.90%;单纯高尿酸血症组分别为46.6%,58.0%;两组差异无统计学意义。高甘油三脂血症与痛风的发生正相关OR=1.29,95%CI(1.12,1.48),高胆固醇血症与痛风的发生负相关OR=0.80,95%CI(0.73,0.89)。结论:痛风与单纯高尿酸血症患者存在不同的脂代谢状态,高甘油三酯血症可能是单纯高尿酸血症发展为痛风的危险因素。
Objective: To compare and analyze the situation of gout and hyperuricemia combined with hyperlipidemia. Methods: Totally 7207 cases of gout (6759 males and 448 females) were admitted to the Gouty Outpatient Department of Affiliated Hospital of Qingdao University from May 2009 to January 2016, 2095 cases of hyperuricemia (1852 males 243 cases). Body height, weight, waist circumference, hip circumference, blood pressure, fasting blood glucose (FPG), triglyceride (TG), blood cholesterol (TC) and serum uric acid (UA) were measured and compared between two groups of hypertriglyceridemia The prevalence of hemophilia, hypercholesterolemia and its independent role in gout development were analyzed. Results: The prevalence rates of hypertriglyceridemia and hypercholesterolemia in gout group were 57.8% and 47.5%, respectively. The hyperuricemia group was 51.8% and 52.9% respectively. The odds ratio Triglyceride 1.274 [95% CI (1.155,1.404)], Cholesterol 0.805 [95% CI (0.730,0.887)]. By gender stratification analysis, the prevalence of hypertriglyceridemia and hypercholesterolemia in male gout group were 56.2% and 46.8% respectively, while those in simple hyperuricemia group were 52.3% and 52.6% respectively. The odds ratio between the two groups was 1.25 [95 CI% (1.13, 1.39)] for hyperglycemia and 0.80 [95 CI% (0.72, 0.89)] for hypercholesterolemia. The prevalence of hypertriglyceridemia and hypercholesterolemia in gout group was 52.2% and 58.90% in women, 46.6% and 58.0% in hyperuricemia group, respectively. There was no significant difference between the two groups. High triglyceridemia was positively correlated with gout OR = 1.29,95% CI (1.12,1.48). The negative correlation between hypercholesterolemia and gout OR was 0.80,95% CI (0.73,0.89). Conclusion: Gout and hyperuricemia patients have different states of lipid metabolism. Hypertriglyceridemia may be the risk factor of developing hyperuricemia to gout.