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有芽胞或无芽胞厌氧菌所致的感染特别引起妇产科工作者的注意。为了治疗或是为了杀灭需氧菌,必须在多种微生物混合感染中消灭厌氧菌。因为许多广泛应用的抗菌制剂(包括某些抗生素)对厌氧菌无效或效弱,故对厌氧菌引起的化脓-败血性感染应用抗菌治疗并不总是成功。这也是寻找有明显抗厌氧菌作用药物的理由。 1972年Nastro和Finegold报导了一种新的硝基咪哒唑制剂——灭滴灵(m etronidazol),对厌氧菌有很强的杀灭作用。这种制剂除用以有效地治疗阿米巴、梨形虫病和滴虫病外,还用于外科治疗由各种厌氧微生物引起的感染。其他硝基咪哒唑制剂有tinidazol、ornidazol、sechidazol和nimo-
Infections caused by spores or spore-free anaerobes are of particular interest to obstetric and gynecological workers. To treat or kill aerobic bacteria, anaerobic bacteria must be eliminated in a variety of microbial mixed infections. Because many widely used antimicrobial agents, including certain antibiotics, are not effective or effective against anaerobic bacteria, antibacterial treatment of suppurative-septic infections caused by anaerobic bacteria has not always been successful. This is also to find a reason for the obvious anti-anaerobic effect of drugs. Nastro and Finegold (1972) reported that a new nitidoconazole formulation, m etronidazol, has a strong killing effect on anaerobic bacteria. In addition to its effectiveness in the treatment of amoeba, pyramidias and trichomoniasis, this preparation is also used to surgically treat infections caused by various anaerobic microorganisms. Other nitro-pidazole formulations are tinidazol, ornidazol, sechidazol and nimo-