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目的 :探讨进展期胃癌围手术期细胞免疫功能的变化。方法 :采用间接荧光法和LDH释放法对 5 2例进展期胃癌围手术期外周血NK细胞活性、T细胞亚群进行检测。结果 :进展期胃癌患者术前外周血NK细胞活性、CD3+ 、CD4+ 细胞明显低于正常对照组 ,CD8+ 细胞却明显增高。术后 ,上述指标均可获得显著改善。结论 :进展期胃癌细胞免疫功能抑制主要是肿瘤负荷所致 ,为改善患者免疫状态 ,应力争外科手术治疗。
Objective: To investigate the changes of cellular immune function in patients with advanced gastric cancer during perioperative period. Methods: Peripheral blood NK cell activities and T cell subsets of 52 patients with advanced gastric cancer were detected by indirect fluorescence and LDH release. Results: The activity of NK cells, CD3 +, CD4 + cells in peripheral blood of patients with advanced gastric cancer were significantly lower than those in normal control group, but CD8 + cells were significantly increased. After surgery, these indicators can be significantly improved. Conclusion: The suppression of immune function of advanced gastric cancer cells is mainly caused by tumor burden. In order to improve the immune status of patients, surgical treatment should be strived.