目的　探讨经皮经肝行胃冠状静脉、胃短静脉栓塞和部分脾动脉栓塞术 (简称双介入法 ) ,治疗肝硬化合并上消化道出血、脾功能亢进的临床意义。方法　对具有完整临床诊断资料的 18例肝硬化合并急性或反复上消化道出血及脾功能亢进的病人 ,采取双介入法用无水酒精、弹簧钢圈、明胶海绵进行胃冠状静脉、胃短静脉及部分脾动脉栓塞 ,其中栓塞胃冠状静脉 18支、胃短静脉 11支 ,脾实质栓塞 5 0 %～ 70 %左右。结果　 18例双介入法手术均顺利完成 ,除栓塞后均有不同程度的发热和脾区疼痛持续 1周～ 1月左右外 ,无特殊并发症发生。术后随访最长 6年 ,最短 4个月 ,18例病人均无再发消化道出血 ,脾功能亢进症状全部改善。结论　双介入法治疗肝硬化合并上消化道出血、脾功能亢进 ,手术操作简便易行 ,临床效果满意 ,值得推广 Objective To investigate the clinical significance of treating gastric cirrhosis with upper gastrointestinal hemorrhage and hypersplenism by percutaneous transluminal coronary angioplasty, short gastric venous embolization and partial splenic arterial embolization (referred to as double intervention). Methods 18 patients with complete cirrhosis with acute or recurrent upper gastrointestinal bleeding and hypersplenism were enrolled in this study. Double coronary artery occlusion And partial splenic artery embolization, including embolization of gastric coronary vein 18, gastric short vein 11, splenic embolization 50% to 70%. Results 18 cases of double interventional surgery were successfully completed, except for embolization have different degrees of fever and spleen pain lasting 1 week ~ 1 month, no special complications. Follow-up up to 6 years after surgery, the shortest 4 months, 18 patients had no recurrence of gastrointestinal bleeding, hypersplenism all improved. Conclusion Double interventional treatment of cirrhosis with upper gastrointestinal bleeding, hypersplenism, surgical operation is simple and easy, the clinical effect is satisfactory, it is worth promoting