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目的 探讨Jun蛋白在颅脑火器伤后早期的表达规律及意义。方法 在德国小口径步枪弹直接致犬颅脑火器伤模型基础上 ,用免疫组织化学的方法检测不同时间点的脑损伤区Jun蛋白的表达 ,并记录脑组织含水量及超微结构的改变。结果 对照组脑组织中几乎无Jun蛋白表达 ,而实验组弹道挫伤区和震荡区的表达始于伤后 30min(P <0 0 5 ) ,1h明显表达 (P <0 0 1) ,6h达到高峰 ,12h后又逐渐下降 ,且挫伤区较震荡区的表达明显 (P <0 0 5 ) ,其与脑水肿的形成呈正相关 (r=0 899,P <0 0 1)。结论 颅脑火器伤后Jun蛋白早期反应性上调 ,是引起脑细胞损害的重要因素
Objective To investigate the expression and significance of Jun protein early after craniocerebral firearm injury. Methods On the basis of the firearm model of canine craniocerebral damage induced by German small-caliber rifles directly, the expression of Jun protein at different time points was detected by immunohistochemistry and the changes of water content and ultrastructure of brain tissue were recorded. Results There was almost no expression of Jun protein in the control group. The ballistic contusion and concussion zone in the experimental group began to express 30 min after injury (P <0 05), 1 h (P 0 01), and peaked at 6 h , And then decreased gradually after 12h. The expression of contusion zone in contusion zone was more obvious than that in concussion zone (P <0.05), which was positively correlated with the formation of cerebral edema (r = 0 899, P <0.01). Conclusion The early reactivity of Jun protein after craniocerebral firearm injury is an important factor that causes brain cell damage