制备粒径均一、单分散、生物可降解的载药微球对于研发缓控释注射微球具有重要的应用价值。本文重点阐述了在制备粒径均一的单分散微球方面已取得成绩的SPG膜乳化法、微流体技术、电喷雾法和声波激发雾化法的技术原理、应用现状、影响因素、技术要点及尚存在的问题等。 Preparation of uniform particle size, monodisperse, biodegradable drug-loaded microspheres for the development of controlled-release injection of microspheres has important application value. This article focuses on the technical principles, application status, influential factors and technical points of the SPG membrane emulsification method, microfluidics, electrospray method and acoustic excitation atomization method that have made great achievements in the preparation of monodisperse microspheres with uniform particle size. There are still problems and so on.