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1975年美国有365,000人死于癌症。同年有665,000名新发癌肿病人。和这个总数相比,中枢神经系统原发肿瘤的数字较小,1975年有8,50O人死亡,10,700名新病例。在这些中枢神经系统肿瘤中估计大约有5千名新发的恶性胶质瘤而且大约有同样数目的病人死亡。比胶质瘤更多的是脑转移癌。死于癌肿者约有18%(67,000)在尸检时有颅内转移。恶性胶质瘤: 恶性胶质瘤的自然病史是熟知的,其平均生存期为4到6月,不到五分之一的病人活到一年,大约仅有10%的病人存活超过2年。卡氮芥(BCNU)、环己亚硝脲(CCNU)及甲基环己亚硝脲均为脂溶性且易于通过血脑屏障,由于治疗动物的实验性脑瘤有效,
In 1975, 365,000 people died of cancer in the United States. In the same year, there were 665,000 new cancer patients. Compared with this total, the number of primary tumors in the central nervous system was small, with 8,500 deaths and 10,700 new cases in 1975. About 5,000 new malignant gliomas are estimated in these CNS tumors and approximately the same number of patients die. More than gliomas are brain metastases. About 18% (67,000) of those who died of cancer had intracranial metastases at the time of autopsy. Malignant gliomas: The natural history of malignant gliomas is well-known, with an average survival of 4 to 6 months. Less than one-fifth of patients live to one year, and only about 10% of patients survive for more than 2 years. . Cardamine mustard (BCNU), cyclohexyluronium (CCNU), and methylcyclohexylnitrosourea are lipid-soluble and readily pass through the blood-brain barrier and are effective in treating experimental brain tumors in animals.