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为了评价前促肾上腺皮质激素(Pro ACTH)对早期发现肺癌的作用,作者进行了前瞻性研究。评价了因胸片异常而入院待诊的100例患者。Pro ACTH浓度用放射免疫和柱层析法测定,根据Pro ACTH浓度作出恶性和非恶性的推测诊断,而后与组织学诊断相比较。为了评价血浆ACTH与肿瘤质量或生长之间的可能关系,在治疗期间对肺癌患者血浆ACTH浓度进行了一系列测定。并在非癌性肺病的研究中,对101例患慢性阻塞性肺病的吸烟者(111个标本),31例肉芽肿性肺病患者和10例急性肺炎患者,进行了一系列血浆ACTH测定。结果发现,74例组织学诊断为肺癌的患者中,有53例(72%)血浆ACTH免疫反应性增高。癌症患者ACTH平均浓度为131.8pg/ml(±SEM为117.5-147.9pg/ml),显著高于正常受试者或胸
In order to evaluate the role of pre-adrenocorticotropic hormone (Pro ACTH) in early detection of lung cancer, the authors performed a prospective study. A total of 100 patients who were admitted to the hospital due to an abnormal chest radiograph were evaluated. The Pro ACTH concentration was determined by radioimmunoassay and column chromatography, and the malignant and non-malignant presumed diagnosis was made based on the Pro ACTH concentration, and then compared with the histological diagnosis. To assess the possible relationship between plasma ACTH and tumor mass or growth, a series of plasma ACTH concentrations were measured during treatment. In a study of non-cancerous lung disease, a series of plasma ACTH measurements were performed in 101 smokers with chronic obstructive pulmonary disease (111 specimens), 31 patients with granulomatous lung disease, and 10 patients with acute pneumonia. The results showed that of 74 patients with histologically diagnosed lung cancer, 53 (72%) had elevated plasma ACTH immunoreactivity. The average concentration of ACTH in cancer patients was 131.8 pg/ml (±SEM was 117.5-147.9 pg/ml), which was significantly higher than that of normal subjects or chest