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目的:探讨特发性血小板减少性紫癜患者(ITP)自身抗体的分布状况。方法:采用间接免疫荧光技术及免疫斑点技术,检测100例ITP患者和30例健康人群血清的抗核抗体(ANA)及抗可提取性核抗原(ENA)。结果:100例ITP患者ANA阳性率为45%,抗ENA阳性率为11%。30例健康人员全部为阴性,差异有显著性。结论:对ITP患者完全有必要检测其自身抗体,尤其对于与自身免疫病相关的自身抗体的核型及高滴度自身抗体的ITP患者要进行随访,以及时发现疾病的可能转归。
Objective: To investigate the distribution of autoantibodies in patients with idiopathic thrombocytopenic purpura (ITP). Methods: The serum anti-nuclear antibody (ANA) and anti-extractable nuclear antigen (ENA) of 100 ITP patients and 30 healthy people were detected by indirect immunofluorescence staining and immunofluorescence staining. Results: 100 cases of ITP patients ANA positive rate was 45%, anti-ENA positive rate was 11%. All 30 healthy people were negative, the difference was significant. Conclusion: It is absolutely necessary for ITP patients to test their autoantibodies. In particular, ITP patients with autoantibodies associated with autoimmune diseases and high titers of autoantibody should be followed up to find out the possible outcome of the disease.