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目的 对肝细胞癌 (HCC)的MRI表现与组织学微血管密度 (MVD)及术后生存期进行相关性研究。方法 对 47例经MR检查、治疗性肝癌切除术和病理证实的HCC进行回顾性研究。结果 47例的MVD值与扰相梯度回波 (spoiledgradientrecalledecho ,SPGR)、T1WI的对比增强率 (CER)呈正相关 (rs=0 .740～ 0 775 ,P <0 .0 5 ) ,多元回归分析显示MVD与平均CER关系更密切。以术后生存时间建立的Cox模型显示 ,MVD越高 ,术后生存时间越短。结论 组织学MVD与HCC术后生存时间密切相关 ;HCC的MR影像能够反映其微血管形成程度 ,从而判断病人的预后。
Objective To investigate the correlation between MRI features, histological microvessel density (MVD) and postoperative survival of hepatocellular carcinoma (HCC). Methods A retrospective study of 47 cases of HCC with MR examination, therapeutic hepatectomy, and histologically confirmed HCC was performed. Results The MVD values of 47 patients were positively correlated with spoiled gradientrecalled echo (SPGR) and contrast enhancement rate (CER) on T1WI (rs=0.740～0 775, P<0.05). Multiple regression analysis showed that MVD is more closely related to the average CER. The Cox model based on postoperative survival time showed that the higher the MVD, the shorter the postoperative survival time. Conclusion The histological MVD is closely related to the survival time of HCC; MR images of HCC can reflect the degree of microvascular formation and thus determine the prognosis of patients.