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目的研究血管肌纤维母细胞瘤的病理特征和免疫组织化学表型以及它的鉴别诊断。方法通过对3例血管肌纤维母细胞瘤的临床表现、病理特征和鉴别诊断以及免疫组化的研究,结合文献复习,总结血管肌纤维母细胞瘤的临床病理和免疫组化特征及鉴别诊断。结果血管肌纤维母细胞瘤均境界清楚,肿瘤由相互交错分布的细胞密集区和细胞稀疏区组成,其间血管丰富,多为毛细血管至中等大薄壁血管;瘤细胞成巢或束状围绕血管周围排列,可见红细胞漏出。免疫表型:肿瘤细胞V im entin、ER和PR阳性,desm in大都数阳性、少数阴性,CD34、CK和S-100蛋白均阴性。结论血管肌纤维母细胞瘤全身多处部位可见,发病部位以女性外阴及盆腔最多见;其生物学行为及组织来源尚无定论,需与侵袭性血管粘液瘤、富于细胞性血管纤维瘤等相鉴别。
Objective To study the pathological features and immunohistochemical phenotype of vascular myofibroblastic tumor and its differential diagnosis. Methods The clinical manifestations, pathological features, differential diagnosis and immunohistochemistry of 3 cases of vascular myofibroblastic tumor were reviewed. The clinicopathological and immunohistochemical features and differential diagnosis of vascular myofibroblastic tumor were summarized. Results Vascular myofibroblastoma was well-defined. The tumor consisted of densely packed cell and sparse cell with staggered distribution. In the meantime, the blood vessels were rich, mostly capillaries to medium-sized large and thin-walled blood vessels. The neoplasms formed nests or bundles around the blood vessels Arranged, visible red blood cells leaked. Immunophenotype: Vim entin tumor cells, ER and PR positive, desm in most of the positive, a few negative, CD34, CK and S-100 protein were negative. Conclusions Vascular myofibroblastoma can be seen in many parts of the body. The incidence of the disease is the most common in the female genital area and the pelvic cavity. The biological behavior and the origin of the tissue are still inconclusive. It needs to be associated with aggressive vascular myxoma, Identification.