传统意义的溶酶体被认为是细胞内消化途径的终点站,是含有多种水解酶和脂肪酶的细胞器,可以消化蛋白以及膜结构等.某些特殊类型的细胞中存在分泌型溶酶体,它既有胞内消化的功能,又有调节分泌功能.在调节溶酶体胞吐的蛋白质中,Rab27a蛋白起到了核心作用.相关基因特别是控制胞吐的基因突变,可造成各种免疫缺陷综合症.星型胶质细胞溶酶体胞吐释放ATP,在神经元和胶质细胞之间传递信息.分泌型溶酶体还参与了肿瘤细胞浸润、转移的过程. Traditionally, lysosomes are thought to be the end point of intracellular digestion, organelles containing many hydrolases and lipases, which can digest proteins and membrane structures, etc. The secretory lysosomes exist in some special types of cells , Which not only has the function of intracellular digestion but also regulates secretory function.The Rab27a protein plays a central role in the regulation of lysosomal exocytosis.Related genes, especially those that control exocytosis, can cause various immunity Defect Syndrome. Astrocyte lysosome exocytosis releases ATP, which transmits information between neurons and glial cells. Secretory lysosomes are also involved in tumor cell infiltration and metastasis.