目的　寻求对大泡性角膜病变有效的治疗方法和效果。 方法　对１２ 例大泡性角膜病变患者的病因进行分析，对治疗方法进行比较。用药物治疗３ 例，采用不同的手术方法治疗９ 例。 结果　１２ 例病例随访６ 个月至６ 年，症状均获缓解，角膜大泡清除，部分病例视力略有提高。 结论　大泡性角膜病变常为眼前段内眼手术的并发症。根据患者角膜病变的程度及视力情况，采用不同的治疗方法，获得了较好的治疗效果 Objective To seek effective treatment and treatment of bullous keratopathy. Methods The etiology of 12 patients with bullous keratopathy was analyzed, and the treatment methods were compared. 3 cases were treated with drugs, and 9 cases were treated with different surgical methods. Results 12 cases were followed up for 6 months to 6 years, the symptoms were relieved, corneal bubble was cleared, and in some cases, the visual acuity slightly increased. Conclusions Bullous keratopathy is often the complication of intraocular surgery in the anterior segment. According to the degree of patients with corneal lesions and visual acuity, the use of different treatment methods, and obtained a better therapeutic effect