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[目的]观察谷胱甘肽能否预防奥沙利铂相关性神经毒性。[方法]49例接受mFOLFOX6方案化疗的结直肠癌患者随机分为治疗组(谷胱甘肽组)和对照组。治疗组(n=28)化疗前静脉滴注谷胱甘肽1.5g/m2,对照组(n=21)化疗前静脉滴注安慰剂。并观察分析两组患者治疗后奥沙利铂相关神经毒性发生率及程度。[结果]8周期化疗后,两组患者神经毒性发生率差异有统计学意义。治疗组Ⅱ～Ⅲ级神经毒性发生率为28.6%,低于对照组为57.1%(χ2=4.055,P﹤0.05)。[结论]化疗前预防应用谷胱甘肽可以减少奥沙利铂相关神经毒性。
[Objective] To observe whether glutathione can prevent oxaliplatin-related neurotoxicity. [Method] Forty-nine patients with colorectal cancer receiving mFOLFOX6 regimen were randomly divided into treatment group (glutathione group) and control group. The patients in the treatment group (n = 28) received intravenous glutathione 1.5 g / m2 before chemotherapy and the control group (n = 21) before chemotherapy. The incidence and extent of oxaliplatin-related neurotoxicity in both groups were observed and analyzed. [Results] After 8 cycles of chemotherapy, the difference of neurotoxicity between the two groups was statistically significant. The incidence of grade Ⅱ ~ Ⅲ neurotoxicity was 28.6% in the treatment group, which was lower than 57.1% in the control group (χ2 = 4.055, P <0.05). [Conclusion] Pretreatment with glutathione can reduce oxaliplatin-related neurotoxicity.