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目的：探讨致病基因多态性与狼疮性肾炎（ＬＮ）患者临床表现及预后之间的关系。方法：应用ＰＣＲ方法分别对９８例和１４４例ＬＮ患者的白细胞介素－１受体拮抗剂（ＩＬ－１ｒａ）和血管紧张素转换酶（ＡＣＥ）基因多态性的分布进行观察，并结合临床病理及随访资料进行分析。结果：携带ＩＬ１ＲＮ＊２等位基因的ＬＮ患者光敏感发生率高，ＬＮ活动性病变明显；ＬＮ患者ＡＣＥ基因ＤＤ基因型的发生频率明显高于正常人（Ｐ＜０．０１），ＤＩ型患者肾脏损害较重，预后较差；ＩＬ－１ｒａ和ＡＣＥ基因多态性在ＬＮ患者的分布无明显相关性。结论：ＬＮ的临床多样性可能与致病基因多态性有一定联系。ＬＮ活动者ＩＬ１ＲＮ＊２等位基因携带率较高，ＬＮ患者ＤＤ基因型发生频率较高，ＤＩ型与病情严重性及不良预后相关，但ＩＬ－１ｒａ和ＡＣＥ基因多态性对ＬＮ的影响无协同作用。
Objective: To investigate the relationship between pathogenic gene polymorphisms and clinical manifestations and prognosis in patients with lupus nephritis (LN). Methods: The polymorphisms of interleukin-1 receptor antagonist (IL-1ra) and angiotensin-converting enzyme (ACE) in 98 patients and 144 LN patients were detected by PCR. Pathology and follow-up data analysis. Results: LN patients with IL1RN * 2 allele had a higher incidence of light-sensitive disease and obvious LN activity lesions. The frequency of DD genotype of ACE gene in patients with LN was significantly higher than that in normal subjects (P <0.01) Severe renal damage, poor prognosis; IL-1ra and ACE gene polymorphisms in the distribution of LN no significant correlation. Conclusion: The clinical diversity of LN may be related to the genetic polymorphism of the disease. LN carriers had higher carrier rate of IL1RN * 2 allele, DD genotype was higher in LN patients, DI type was associated with serious illness and poor prognosis, but the effects of IL-1ra and ACE gene polymorphisms on LN Synergy.