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目的:探讨山西省雁同地区鼻咽部淋巴瘤的特点及其与EB病毒相关性。方法:用免疫组织化学(LSAB)法及EB病毒寡核苷酸探针(EBER)原位杂交,检测30例在当地生活10 a以上的鼻咽部淋巴瘤肿瘤细胞的免疫表型及EBV感染情况,分析其特点及与EB病毒的关系。采用χ2检验和t检验进行统计学处理。结果:经免疫组化证实,30例中,27例为T细胞性淋巴瘤(90 %),3例为B细胞性淋巴瘤(10 %),EBV-EBER原位杂交,T细胞性淋巴瘤均为阳性,B细胞性淋巴瘤均为阴性。结论:山西省雁同地区鼻咽部淋巴瘤患者绝大多数为T细胞性淋巴瘤,根据其细胞形态特点,来判断T细胞性淋巴瘤,与免疫组化对照符合率为76.6 %(23/30),正确率较高,可作为基层医院防止对鼻咽部淋巴瘤漏诊的一个方法。鼻咽部T细胞性淋巴瘤与EBV显著相关。
Objective: To investigate the characteristics of nasopharyngeal lymphoma and its relationship with Epstein-Barr virus in Yanntong area of Shanxi Province. Methods: Immunohistochemistry and EBV infection of 30 cases of nasopharyngeal lymphoma cells living in the local area for more than 10 years were detected by immunohistochemistry (LSAB) and EB virus DNA probe (EBER) in situ hybridization Situation, analyze its characteristics and the relationship with the Epstein-Barr virus. Using χ2 test and t test for statistical analysis. Results: Of the 30 patients, 27 were T-cell lymphoma (90%), 3 were B-cell lymphoma (10%), EBV-EBER in situ hybridization, T cell lymphoma All were positive, B cell lymphoma were negative. Conclusion: The majority of patients with nasopharyngeal lymphoma in YanTong area of Shanxi Province are T-cell lymphoma, and T-cell lymphoma is judged according to their cell morphology. The coincidence rate with the immunohistochemical method is 76.6% (23 / 30), the correct rate is higher, can be used as a primary hospital to prevent missed diagnosis of nasopharyngeal lymphoma a method. Nasopharyngeal T-cell lymphoma was significantly associated with EBV.