【摘 要】
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Cellular senescence marked with persistent cell cycle arrest plays critical roles in orchestrating tissue remodeling and immune surveillance in response to mult
【机 构】
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National Key Laboratory of Medical Molecular Biology, Department of Immunology & Center for Immunoth
论文部分内容阅读
Cellular senescence marked with persistent cell cycle arrest plays critical roles in orchestrating tissue remodeling and immune surveillance in response to multiple developmental and physiological stimuli.However,chronic or persistent cellular senescence can promote aberrant inflammatory responses,therefore is linked with variable pathogeneses such as fibrosis,cancer,autoimmune diseases,cardiovascular disease and neurodegenerative disease [1].Identifying how the immune system detects and responds to senescence signals is critical for our better understanding of the interplay between senescence progression and inflammation,and the pathogenesis of age-related diseases [1].
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