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目的:检测冠心病(CHD)及冠心病合并糖尿病(DM)患者血浆中profilin-1、晚期糖基化终产物受体(RAGE)的水平,并进一步探讨其临床意义。方法:入选89例研究对象,其中对照组27例,CHD组31例,CHD合并DM组31例。空腹采集外周静脉血,采用ELISA法检测血浆profilin-1与RAGE水平;收集一般临床资料及常规生化指标,根据Gensini积分系统计算冠状动脉(冠脉)狭窄程度。结果:1CHD组和CHD合并DM组患者血浆profilin-1及RAGE水平以及Gensini积分明显高于对照组(P<0.05),CHD合并DM组更为明显(P<0.05);2血浆profilin-1水平与RAGE水平呈正相关(R2=0.716 1,P<0.05),血浆profilin-1、RAGE水平与Gensini积分呈正相关(R2=0.749 4、0.842 4,P<0.05)。结论:CHD合并2型DM患者血浆profilin-1与RAGE水平明显高于单纯CHD患者,且profilin-1与RAGE水平与Gensini积分呈正相关,提示血浆profilin-1与RAGE水平可在一定程度上反映冠脉狭窄程度。
Objective: To detect the levels of profilin-1 and advanced glycation end-products receptor (RAGE) in plasma of patients with coronary heart disease (CHD) and coronary heart disease complicated with diabetes mellitus (DM) and to explore its clinical significance. Methods: A total of 89 subjects were enrolled, including 27 in control group, 31 in CHD group and 31 in CHD combined with DM group. Peripheral venous blood was collected on fasting day, and plasma levels of profilin-1 and RAGE were measured by ELISA. General clinical data and routine biochemical indexes were collected. The degree of coronary artery (coronary artery) stenosis was calculated according to Gensini integral system. Results: The levels of profilin-1, RAGE and Gensini in patients with CHD and CHD combined with DM were significantly higher than those in control group (P <0.05), and those in CHD combined with DM group were more obvious (P <0.05) .2 Levels of plasma profilin-1 (R2 = 0.716 1, P <0.05). The levels of plasma profilin-1 and RAGE were positively correlated with Gensini score (R2 = 0.749 4,0.842 4, P <0.05). CONCLUSIONS: The levels of profilin-1 and RAGE in patients with CHD complicated with type 2 DM are significantly higher than those with simple CHD, and the levels of profilin-1 and RAGE are positively correlated with Gensini scores, suggesting that plasma profilin-1 and RAGE levels may reflect to some extent Stenosis.