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1948年,Morrlson等人前先从正常人的血浆中分离出一种不溶性冷球蛋白,它不同于纤维蛋白原,经凝血酶处理后,不能使其凝固。以后,人们对此蛋白进行了大量的研究,发现这种蛋白广泛存在于体液和细胞外基质,在免疫、血凝及血小板凝集等方面具有生物活性。此蛋白的命名比较混乱,曾称为可溶性成纤维细胞抗原、细胞表面蛋白、细胞粘附因子和调理蛋白等。直到70年代,人们才广泛应用纤维结合蛋白(Fibronectin,FN)的名称。自从1978年,Scheinman首次描述FN在肾小球内的定位以来,许多学者对FN在各种肾小球肾炎的肾组织分布以及血浆FN(P-FN)浓度的变化进行了观察,本文就这方面的研究近况作一介绍。一、FN的生物特性
In 1948, Morrlson and others previously isolated from normal human plasma an insoluble cryoglobulins, which is different from fibrinogen, after thrombin treatment, can not make it solidified. Since then, a large number of studies have been carried out on this protein and found that this protein exists widely in body fluids and extracellular matrix and has biological activity in immunity, blood clotting and platelet aggregation. The name of this protein is quite confusing and has been called as soluble fibroblast antigen, cell surface protein, cell adhesion factor, and opsonin. Until the 1970s, the name of fibronectin (FN) was widely used. Since 1978, when Scheinman first described the localization of FN in the glomerulus, many scholars have observed the distribution of FN in renal tissue and the changes of plasma FN (P-FN) concentrations in various glomerulonephritis. The research status of the area for an introduction. First, the biological characteristics of FN