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目的:探讨西宁地区妊娠早期正常单胎颈项透明层(nuchal translucency,NT)的参考值范围。方法:对2012年8月—2013年4月在青海红十字医院产科就诊的妊娠早期(孕11~13~(+6)周)单胎孕妇超声测量胎儿颈项透明层厚度共393例为观察对象,参照英国胎儿基金会(FMF)的标准超声测量胎儿头臀径(CRL)及NT厚度,初步建立西宁地区妊娠早期正常单胎胎儿NT厚度的参考值范围。结果:纳入研究的正常单胎,NT厚度测量值95%CI(1.1,3.1)mm,中位数为1.9mm。结论:本研究进一步证实了妊娠早期胎儿NT厚度与CRL的相关性,绘制出西宁地区妊娠早期正常单胎不同CRL对应的NT厚度的参考值范围,为今后高海拔地区推广产前筛查工作提供一定的参考。
Objective: To explore the reference range of nuchal translucency (NT) in normal pregnancy during the first trimester of pregnancy in Xining. Methods: A total of 393 cases of fetal neck transparent layer thickness were measured by ultrasonography in the first trimester of pregnancy (11 ~ 13 ~ (+6) weeks pregnant) from August 2012 to April 2013 in Qinghai Red Cross Hospital. The reference value range of NT thickness of normal singleton fetuses in early pregnancy of Xining was preliminarily established according to the standard ultrasonic measurement of fetal head hip diameter (CRL) and NT thickness of the British Fetal Foundation (FMF). RESULTS: Normal singletons included in the study were NT 95% CI (1.1, 3.1) mm with a median of 1.9 mm. CONCLUSIONS: This study further confirmed the correlation between NT thickness and CRL in early gestation and plotted the reference range of NT thickness corresponding to different CRL of normal singleton in early pregnancy in Xining. It provides the basis for the promotion of prenatal screening in high altitude area in the future Certain reference.