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目的探讨连续性血液净化(CBP)治疗严重烧伤患者的疗效及可能机理.方法选取2005年5月~2011年5月住院治疗的、接受系统烧伤治疗和床边CBP的24例烧伤病人,观察治疗前后C反应蛋白(CRP)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNFα)、动脉血气、血电解质和肾功能等生化指标的变化,并与同期住院的轻度烧伤病人比较.结果24例治愈20例.CBP治疗前血清CRP、IL-6、TNF、K+、BUN、Cr等均明显高于对照组,动脉血气示严重缺氧和酸中毒.CBP治疗后,上述指标较治疗前显著改善,且与对照组无统计学差异.结论 CBP治疗严重烧伤患者,可清除血中过度的炎性介质、细胞因子等,纠正水电解质酸碱平衡紊乱,下调代谢产物水平,缓解低氧血症,改善氧合水平,从而提高治愈率.“,”Objective To explore the therapeutic effects and possible mechanism of continuous blood purification(CBP) in treatment of severely burned victims.Methods 24 severely burned patients admitted in our department from May 2005 to May 2011 were studied as treatment group.The patients were treated with systemic comprehensive therapeutics combined with bedside CBP.Before and after CBP,the serum levels of C-reaction protein(CRP),interleukin-6(IL-6),tumor necrosis factor α(TNFα) were measured.The blood biochemical data and arterial blood gases were also detected.All of these testing results were statistically analyzed,and compared with the results of mild burn patients in control group.Results 20 cases were survival and 4 cases died.Before CBP,the levels of CRP,IL-6,TNFα,K+,BUN,Cr were higher than those in control group markedly,while the arterial blood gases showed severe anoxia and acidosis.After CBP,the above data were significantly improved compared with those of before CBP,and no statistical differences compared with those in control group.Conclusion In the treatment of severely burned patients,CBP can remove excessive inflammatory factors and cytokines,correct water-electrolyte imbalances,eliminate metabolic product,relieve the hypoxemia and improve oxygenation,thus enhances curing rate.