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目的 观察慢性次声暴露对豚鼠听阈及耳蜗毛细胞形态学的影响和作用特点 .方法 通过听觉脑干诱发电位测试 (ABR)及扫描电镜分别观察了豚鼠在 8Hz,1 2 5 d B SPL ,1次· d- 1 ,2 h/次的次声暴露条件下 ,其听阈和耳蜗毛细胞听毛形态的变化情况 .结果 豚鼠在 click声及 9个频率的短纯音的听阈均有升高 ,最大阈移为 2 6 d B (4k Hz短纯音 ) ,最小阈移为 1 8d B(click声 ) ;豚鼠听阈的升高缺乏频率选择性 ,各频率阈移间无显著差异 .扫描电镜观察可见耳蜗毛细胞出现了以外毛细胞为主的损伤表现 ,且由底周至顶周外毛细胞听毛的损伤逐渐加重 .结论 慢性次声暴露确可使豚鼠听力出现下降 ,但与白噪声相比其又有自己的声损伤特点 ,可能在声损伤机制上二者是有差别的 .
Objective To observe the effects of chronic infrasound on auditory threshold and morphology of cochlear hair cells in guinea pigs.Methods The expressions of SPL1 and CTL at 12 and 8 days after guinea pigs were observed by auditory brainstem response test (ABR) and scanning electron microscopy Times of d-1, 2 h / times under the infrasound exposure conditions, the auditory threshold and cochlear hair cells listen to the change of hair morphology.Results Guinea pigs in the click sound and nine frequencies of short pure tone threshold were increased, the maximum The threshold shift was 26 dB (4 k Hz short pure tone) and the minimum threshold shift was 18 dB (click sound). There was no frequency selectivity in guinea pigs with elevated threshold, and there was no significant difference between the thresholds. Hair cells appeared outside the hair cell-based damage performance, and from the pericycle to the top peripheral hair cells to listen to hair damage gradually increased.Conclusion Chronic infrasound exposure can indeed make guinea pigs hearing loss, but compared with the white noise Have their own characteristics of acoustic damage may be the mechanism of sound damage on the two are different.