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目的 探讨年龄对二甲苯神经毒作用的影响。方法 采用 Ｈ Ｅ 染色法和 Ｔ Ｕ Ｎ Ｅ Ｌ 技术对不同月龄大鼠的脑组织病理形态学和神经细胞凋亡情况进行了研究。结果 二甲苯５００ ｍ ｇ／ｋｇ 染毒后，２ 月龄组较８ 月龄组大鼠脑组织形态学改变相对严重，２ 月龄组染毒大鼠神经细胞凋亡的发生率为（１ ．５３ ±１ ．０６） 个／ 视野，明显高于同龄对照组的（０ ．９３ ±０ ．７５） 个／ 视野， Ｆ＝ １２ ．６５９ ６ ， Ｐ＜ ０ ．００１ ；８ 月龄组染毒大鼠的神经细胞凋亡率为（１ ．６５ ±１ ．１１） 个／ 视野，明显高于同龄对照组的（１ ．１５ ±１ ．０７） 个／ 视野， Ｆ＝ ６ ．２６３ ３ ， Ｐ＜ ０ ．０５ 。结论 低龄大鼠对二甲苯的神经毒作用更为敏感
Objective To investigate the effect of age on the neurotoxic effect of xylene. Methods H e staining and T U N E L were used to study the histopathology and neuronal apoptosis in different months of age. Results After exposure to 500 m g / kg xylene, the morphological changes of brain tissue in 2-month-old rats were more serious than those in 8-month-old rats. The incidence of neuronal apoptosis in 2-month-old rats was (1. 53 ± 1 .06) pigs per field of view, which was significantly higher than that of the control group of the same age (0.93 ± 0.75) pigs / field, F = 12. 659 6, P <0. 001; the apoptotic rate of neurons in the 8-month-old rats was (1.65 ± 1.11) / field, which was significantly higher than that of the control group (1.15 ± 1.07) / field of vision, F = 6. 263 3, P <0. 05. Conclusion The neurotoxicity of para-xylene in younger rats is more sensitive