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目的分析近年来小儿药物性肝炎增多的原因及临床特点,指导临床减少儿童药物性肝损害的发生。方法回顾分析小儿药物性肝炎77例,对其用药史、时间分布、年龄分段、临床表现,肝功能、血常规检查进行总结。结果77例小儿药物性肝炎占同期小儿肝炎发病率的10.42%;1岁以内的患儿发生药物性肝炎达36.36%。混合型药物性肝炎患儿病程长,病情重,治疗难度大。结论临床治疗中,充分了解药物的副作用,严密观察患儿有关肝病的症状和体征,并定期检测肝功能,是预防和减少儿童药物性肝损害的重要手段之一。
Objective To analyze the causes and clinical features of pediatric patients with drug-induced hepatitis in recent years, and to guide the clinical treatment of drug-induced liver damage in children. Methods Retrospective analysis of 77 cases of pediatric drug-induced hepatitis, the history of drug use, time distribution, age, clinical manifestations, liver function, blood tests were summarized. Results 77 pediatric drug-induced hepatitis accounted for 10.42% of the incidence of pediatric hepatitis in the same period; children with 1-year-old drug-induced hepatitis reached 36.36%. Children with mixed drug-induced hepatitis have long course, heavy illness and difficult treatment. Conclusions In clinical treatment, it is one of the important ways to prevent and reduce drug-induced liver damage in children by fully understanding the side effects of drugs, closely observing the symptoms and signs of liver disease in children, and regularly detecting liver function.