虽已对美洲钩虫及十二指肠钩虫引起的钩虫病进行了多方面的防治,该病却仍在广泛流行。以往人们常以粪便中虫卵密度间接反映感染强度,现在则依据药物的驱虫数。但这两种方法均受社会及经济条件的限制。尽管血清学方法十分敏感,但目前尚未广泛应用。本文作者研究了美洲钩虫同种型特异反应与年龄、性别和感染状态之间的关系,以探讨对成虫抗原的IgG4应答用于流行病学调查的可能性。 Although the hookworm disease caused by hookworm and duodenal hookworm has been multifaceted prevention and treatment, the disease is still widespread. In the past, the density of feces in eggs is often used to indirectly reflect the intensity of infection, but now based on the number of drug repellent. However, both methods are subject to social and economic constraints. Although serological methods are very sensitive, they are not yet widely used. The authors studied the relationship between hookworm isotype-specific responses and age, sex, and infection status in order to explore the possibility of using IgG4 responses to adult antigens for epidemiological investigations.