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大连市人群中2型糖尿病(T2DM)194例,正常空腹血糖(NFG)127例,应用PCR基因扩增、限制性内切酶基因多态性方法,对PPAR-δ基因的-87位点T→C的变异,进行基因型和等位基因分析。发现T2DM与NFG两组间不存在基因型频度分布的明显差异。但是,T2DM组内的BMI呈现基因型之间的明显差异;NFG组内,HOMA-IR存在不同基因型之间的明显差异。
194 cases of type 2 diabetes mellitus (T2DM) and 127 cases of normal fasting plasma glucose (NFG) in population of Dalian were enrolled in this study. The polymorphisms of PPAR-δ gene at -87 site T → C variation for genotype and allele analysis. There was no significant difference in the frequency distribution of genotype between T2DM and NFG. However, BMI in T2DM group showed significant difference between genotypes; there was significant difference between HOMA-IR genotypes in NFG group.