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作者用定量溶血分光光度法(QHS)同时测定正常和荷瘤BALB/c小鼠各40只脾脏抗体形成细胞的变化,观察蚯蚓提取物对B细胞介导的免疫应答的影响。结果表明,蚯蚓提取物连续灌胃7d后,使正常小鼠脾脏抗体形成细胞由1.117±0.035增至1.291±0.103(OD值)(P<0.01);荷瘤小鼠由 l.045±0.062增至1.343±0.173(P<0.01)。提示蚯蚓提取物能调节B细胞的增殖和分化,使特异性抗体形成和分泌增加。
The authors used quantitative quantitative hemolysis spectrophotometry (QHS) to simultaneously measure the changes of 40 spleen antibody-forming cells in normal and tumor-bearing BALB/c mice and to observe the effects of sputum extract on B cell-mediated immune responses. The results showed that the spleen antibody-producing cells of normal mice increased from 1.117±0.035 to 1.291±0.103 (OD) (P<0.01), and the tumor-bearing mice increased from 1.045±0.062 after continuous gavage for 7 days. To 1.343±0.173 (P<0.01). It is suggested that extracts of Smilax can regulate the proliferation and differentiation of B cells and increase the formation and secretion of specific antibodies.