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人肝细胞生长因子(hHGF)系由重症肝炎患者血液精制而成,是大鼠第一代培养肝细胞的增殖促进因子。其血中浓度在重症肝炎患者中与肝昏迷程度呈正相关,而在肝硬化患者则与血清白蛋白呈负相关。但对肝功能不全的诊断价值如何还不甚明瞭,本文根据新设计的ELISA法对此进行了研究。对象和方法符合犬山会议诊断标准的重症肝炎患者(急性肝功能不全组)16例,发病前没有明显的血清转氨酶升高,而肝性脑病在Ⅱ°以上,凝血酶原时间在40％以下的肝硬比患者(慢性肝功能不全组)16例为对象。经ELISA法测定,血中hHGF的正常值为3.4μg/L以下。结果急性肝功能不全组血中平均hHGF值比慢
Human hepatocyte growth factor (hHGF) is derived from the blood of severe hepatitis patients and is the first generation of rat hepatocyte proliferation promoting factor. The blood concentration in patients with severe hepatitis and hepatic coma degree was positively correlated, while patients with cirrhosis and serum albumin was negatively correlated. However, it is unclear how to diagnose hepatic insufficiency. In this paper, a new designed ELISA was studied. Subjects and Methods Sixteen patients with severe hepatitis (Acute Hepatic Insufficiency Group) meeting the diagnostic criteria of Inuyama meeting had no significant increase of serum aminotransferase before the onset of disease, while hepatic encephalopathy was above Ⅱ ° and prothrombin time was below 40% 16 patients with liver cirrhosis (chronic hepatic insufficiency) as the object. The ELISA method determined that the normal blood hHGF was 3.4μg / L or less. Results The mean hHGF in blood of patients with acute hepatic insufficiency was slower than that of patients with acute hepatic insufficiency