论文部分内容阅读
胃粘膜肠上皮化生及其与胃癌发生之间的关系是当今胃粘膜临床与病理研究的热点课题。在内镜胃粘膜活检中,肠化生病人非常多见,因此,深入开展对肠化生的研究具有重要的现实意义。本文收集有关文献,就此领域的研究历史、现状与未来进行概述,并试图提出肠化生与胃癌关系的设想模式。胃粘膜肠化生研究的历史回顾 1883年Kupffer在对胃癌切除标本进行形态学观察中首次描述了胃粘膜的肠化生现象,当时认为是一种胚胎残留组织或单纯的肠粘膜异位。1896年Schmidt发
The relationship between gastric mucosal intestinal metaplasia and the occurrence of gastric cancer is a hot topic in the clinical and pathological research of gastric mucosa. In the endoscopic gastric mucosal biopsy, the patients with intestinal metaplasia are very common. Therefore, it is of great practical significance to conduct in-depth research on intestinal metaplasia. This article collects relevant literature, gives an overview of the research history, current status, and future of this field, and tries to propose a hypothetical model for the relationship between intestinal metaplasia and gastric cancer. History of Gastric Mucosal Intestinal Metaplasia Research In 1883, Kupffer described for the first time the intestinal metaplasia of gastric mucosa in a morphological observation of resection specimens of gastric cancer. At that time, it was considered to be an embryonic residual tissue or a simple intestinal heterotopic lesion. 1896 Schmidt made