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过去15年对前列腺素的大力研究,说明这类物质广泛存在于哺乳动物组织中,它可能通过一种和腺苷酸环化酶还没有弄清特性的相互作用关系,对内分泌、生殖、神经、消化、凝血、呼吸、心血管和肾脏等系统都能产生强烈的生理作用,此外还能调节脂质和醣类代谢。这些生理作用的阐明,提示前列腺素的产生或代谢上的改变,可能要引起诸如不孕症、痛经、消化性溃疡、腹泻、支气管收缩性病变和高血压等的障碍.不过前列腺素类化合物对人体生理和病理的明确影响,还有待于其精确的定性和定量方法的发明。最近对一些结构上和前列腺素有关,能选择性地和前列腺素E_1和F_(1α)进行竞争性拮抗的物质的合成,可能会迅速解决前列腺素的一些生理作用问题。最近几年,在治疗上已用于引产、治疗性流产,並建议用于治疗不孕症、消化性溃疡、哮喘、休克、高血压和充血性心力衰竭。这是值得在现有报告的基础上,对其在正常和不同疾病上的作用进行更详细的研究的。
The vigorous study of prostaglandins over the past 15 years has shown that such substances are widespread in mammalian tissues and may exert their effects on endocrine, reproductive, and nerve responses through an interaction that has not yet been characterized by adenylate cyclase , Digestion, coagulation, respiration, cardiovascular and kidney systems can produce a strong physiological role, in addition to regulating lipid and carbohydrate metabolism. The elucidation of these physiological effects suggests that prostaglandin production or metabolic alterations may cause disorders such as infertility, dysmenorrhea, peptic ulcer, diarrhea, bronchoconstrictive lesions and hypertension, etc. However, prostaglandin-like compounds The clear impact of human physiology and pathology remains to be seen in its precise qualitative and quantitative inventions. The recent synthesis of some substances that are structurally related to prostaglandins and are able to selectively compete with prostaglandins E_1 and F_ (1a) may promptly address some of the physiological effects of prostaglandins. In recent years, it has been used therapeutically for induction of labor and therapeutic abortion and is recommended for the treatment of infertility, peptic ulcer, asthma, shock, hypertension and congestive heart failure. It is worth undergoing a more detailed examination of its role in normal and different diseases, based on the available reports.