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目的： 观察视黄醇、视黄酸、维生素Ａ 醋酸酯三种类维生素Ａ（类ＶＡ）在体外对正常人外周血单个核细胞（ＰＢＭＣ）中淋巴细胞白细胞介素２ 受体（ＩＬ－２Ｒ）表达、白细胞介素２（ＩＬ－２）分泌及单核细胞分泌白细胞介素１（ＩＬ－１）的影响。方法： 分别测定１０－ １０～１０－ ６ｍ ｏｌ／Ｌ浓度范围三种类ＶＡ作用下ＩＬ－２ 受体表达、ＩＬ－１、ＩＬ－２ 含量，再测定、比较三种类ＶＡ在１０－ ９浓度时上述作用大小。结果： 在一定浓度（１０－ １０～１０－ ７ｍ ｏｌ）范围，三种物质能不同程度促进高亲和力ＩＬ－２Ｒ表达和ＩＬ－１、ＩＬ－２ 分泌。结论： 类ＶＡ可能作用于ＰＢＭＣ活化早期，促进其功能，且作用大小与类ＶＡ种类及浓度有关。
Objective: To observe the effects of retinol, retinoic acid and vitamin A acetate on the expression of interleukin 2 receptor (IL-2R) in peripheral blood mononuclear cells (PBMC) (IL-2) secretion and interleukin-1 (IL-1) secretion by monocytes. Methods: The levels of IL-2 receptor, IL-1 and IL-2 were measured under the action of three kinds of VA in the concentration range of 10- 10 -6 mol / L, respectively. The levels of IL- The role of the size. Results: The three substances could promote the expression of IL-2R with high affinity and the secretion of IL-1 and IL-2 in a certain range of concentration (10-10 ~ 10-7 mol). Conclusion: VA may act on the early activation of PBMC to promote its function, and the size and role of VA-like species and concentration.