肺泡巨噬细胞 (AM )是气道的主要防御细胞。吸烟者AM凋亡减少 ,氧化应激中重要的抑制性调节因子P2 1CIP1/WAF1和抗凋亡调节因子Bcl XL 表达增加。报道如下 :方法　实验对象分组为健康的吸烟者 10例 ,非吸烟正常人 6例 ,哮喘患者 7例。行纤维支气管镜及活检、支气管肺泡灌洗及AM Alveolar macrophages (AMs) are the major defensive cells in the airways. Apoptosis AM decreased in smokers, and the expression of P2CIP1 / WAF1 and Bcl XL, which are important inhibitory regulators of oxidative stress, were increased. Reported as follows: Methods The subjects were grouped into 10 healthy smokers, 6 non-smokers normal, 7 asthma patients. Line fiberoptic bronchoscopy and biopsy, bronchoalveolar lavage and AM