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目的：探讨偏头痛患者发作间期颅内血管血流动力学与甲襞微循环改变的关系。方法：对５０例偏头痛患者采用经颅多普勒（ＴＣＤ）检测颅内血管血流动力学与甲襞微循环仪检测患者左手无名指甲襞微循环指标，并与健康体检者进行对照分析。结果：偏头痛组患者ＴＣＤ示颅内动脉血流速度增快，并明显高于对照组（Ｐ＜０．０５）。头痛组甲襞微循环也呈相应的微血管狭窄，张力增加，加权积分值也明显高于对照组（Ｐ＜０．０５～０．００１）。结论：偏头痛患者发作间期颅内血管血流动力学异常与甲襞微循环的异常有密切关系。临床上可采用简便、无创的甲襞微循环检测方法，获得人体微循环信息，间接反映颅内血流动力学状态，动态地监测患者病情。
Objective: To investigate the relationship between the intracranial vascular hemodynamics and the microcirculation of formazan during the onset of migraine. Methods: Fifty patients with migraine were examined by transcranial Doppler (TCD) for intracranial vascular hemodynamics and nailfold microcirculation. The indexes of left and right handedness were analyzed and compared with those of healthy subjects. Results: TCD in the migraine group showed that the intracranial arterial blood flow velocity was faster than that in the control group (P <0.05). The microcirculation of nail polish in headache group also showed the corresponding microvascular stenosis, the tension increased, and the weighted integral value was also significantly higher than that of the control group (P <0.05 ~ 0.001). Conclusion: The intracranial hemodynamic abnormality in interictal migraineurs is closely related to the abnormality of microcirculation of formazan. Clinically, a simple and non-invasive nail loop microcirculation detection method can be used to obtain the microcirculation information of the human body, which indirectly reflects intracranial hemodynamic status and dynamically monitors the patient’s condition.