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在酵母诱导的发热大鼠中,桂枝汤有效部位A(Fr.A)能降低隔区AVP和下丘脑NT含量,对下丘脑AVP含量无影响;在安痛定诱导的低体温大鼠中,Fr.A能提升下丘脑、隔区AVP含量和下丘脑NT含量。结果提示,Fr.A对发热动物的解热作用与影响下丘脑NT和隔区AVP的释放有关;抑制中枢AVP和NT的释放或利用参予Fr.A对低体温的调节过程
In yeast-induced febrile rats, the effective fraction of Guizhitang A (Fr.A) reduced the AVP content in the septal area and NT content in the hypothalamus, but had no effect on the AVP content in the hypothalamus; it was also found in the hypothermia-induced hypothermia rats. , Fr. A can increase the content of AVP and hypothalamic NT content in hypothalamus and septum. The results suggest that Fr. The antipyretic effect of A on fever animals is related to the release of AVP in the hypothalamus NT and septal area; inhibition of central AVP and NT release or use of Fr. A regulation of hypothermia